Rabbits as models for impotence research. Penile erection in the primate: induction with nitric oxide donors. Hellstrom WJ, Monga M, Wang R, Doner FR, Kadowitz PJ, Roberts JA. Implantable penile venous compression device: initial experience in the acute canine model. Paick JS, Marc B, Suh JK, Batra AK, Lue TF, Tanagho EA. The effect of vascular endothelial growth factor on a rat model of traumatic arteriogenic erectile dysfunction. Lee MC, El-Sakka A, Graziottin TM, Ho HC, Lin CS, Lue TF. Rodents in impotence research: functional and genetic aspect. Functional measurements of penile erection in feline, canine and primate animal models. Effect of experimental hypercholesterolemia on cavernosal structures. Organization and relative content of smooth muscle cells and extracellular matrix components in the corpus cavernosum of the rat penis. Pinheiro ACAD, Costa WS, Cardoso LEM, Sampaio FJB. The present data should therefore provide important information for devising experiments and interpreting results when using the rabbit penis as a model for penile dysfunctions, especially when making comparisons with humans. The great amount of elastic fibers distribution beneath the endothelium suggest that these fibers may have an important role in the erection process in rabbits. Results for CC and CS were not significantly different. The histochemical methods detected elastic system fibers in CS, CC and TA of all animals. The elastic system fibers Vv (%) was determined in 25 random fields of each fragment, using the M-42 test grid. The sections were stained with Weigert's Fucsin–Resorcin with previous oxidation. The penile mid-shaft fragments were fixed with 4% phosphate-buffered formalin solution and/or Bouin's liquid for 24–48 h, and processed using standard histological techniques. Adult New Zealand rabbits ( n=10) were used. We characterized and quantified the volumetric density (Vv) of the elastic system fibers in the corpus spongiosum (CS), CC and tunica albuginea (TA) of the rabbit penis. ![]() ![]() ![]() Although investigations of these issues have used the rabbit CC, organization of its components is not well known to date. The corpus cavernosum (CC) extracellular matrix is essential for normal penile erection and is implicated in erectile dysfunction.
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